
/ CAPABILITIES AND EXPERTISE /
Solutions to HEOR Methodology Challenges
We provide subject matter expert (SME) to guide the application of methods in RWE, Health Economic (HE) Modeling and Evidence Synthesis studies that meets rigorous value evidence demonstration requirements. This includes guidance on design, choice of appropriate research method(s), their application, analysis and reporting, interpretation, and critique of methods.
Types of Econometrics/Statistical Models & Analytics
Cross-Sectional, Time Series, and TSCS/Panel/Longitudinal, ECA, SCA designs
Explanatory, Predictive, and Causal Analysis
Linear Probability Models
LDV: Logit, Probit, Tobit, Ordered Logit, Conditional Logit, MNL/MNP
Poisson, Negative Binomial, Zero-Inflated, Left-Truncated
Generalized Linear Model (GLM) with appropriate distribution and link function
Duration/Survival Analysis: Nonparametric, Semi-parametric (Cox PH), Parametric
Oaxaca-Blinder Decomposition AnalysisQuasi-Experimental: PSM w/IPTW, D-i-D, Interrupted Time Series (ITS)
Time Series: ARIMA, SARIMA, Spatial AR
Endogeneity Correction Model using IV: 2SRI, N-SLS, GMM
Panel/Longitudinal Data Methods: FE, RE, ME, Hierarchical, DynamicSpecial Challenges: Missingness & Imputation, Reporting of Linear vs. Nonlinear Models' effects, Censoring (Left, Right, Interval), Frailty, Competing Risks, Time-varying Covariates (TVC), Monotonicity/Non-Monotonicity
Pre-/Post-Estimation Diagnostics: Nonnormality, Linearity, Homoscedasticity, Independence, Multicollinearity, Serial Correlation, Errors in Variables, Endogeneity, Identification, Orthogonality, Model Specification and Fit
Real World Data (RWD) Evaluation
We assist clients in identifying, profiling and evaluating fit-for-purpose Real World Data (RWD) via checks for relevance, accuracy, plausibility of data ranges, completeness and benchmarking to reference databases for reliability. These activities are intended to help meet recommended guidelines from regulatory and health technology assessment bodies (e.g., FDA RWE Framework, EMA RWE initiatives, NICE RWE guidance).
Health Economic Modelling Methods & Analytics
We provide expert consultation and guidance on appropriate model structure, schema, input parameters including plausibility of assumptions and expert opinions, output/outcome measures, presentation and interpretation of results, sensitivity analysis and critique to ensure that clients' health economic models meet the needs and standards of payers, insurers, HTA bodies (e.g., NICE, CADTH, PBAC, IQWiG, HAS, ICER, VA) and other stakeholders.
Evidence Synthesis Methods & Analytics
We provide comprehensive expert consultation and guidance for clients across both qualitative and quantitative Evidence Synthesis deliverables. This involves working directly with you on projects ranging from focused literature reviews to complex statistical integration. On the quantitative side, this includes advanced methodologies such as Meta-Analysis (MA), Network Meta-Analysis (NMA), and Meta-Regression, ensuring robust data synthesis and interpretation for value demonstration.
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